GNF-8625

• Description:

  GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.

• UNSPSC:

  12352005

• Target:

  Ligands for Target Protein for PROTAC; Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gnf-8625.html

• Smiles:

  FC1=CC=CC ([C@@H]2N (CCC2) C3=NN4C (C5=CC=CC (C6=CC=NC (N7CCC (CC7) O) =C6) =N5) =CN=C4C=C3) =C1

• Molecular Formula:

  C31H30FN7O

• Molecular Weight:

  535.61

• References & Citations:

  [1]Selectively targeting tropomyosin receptor kinase a (TRKA) via PROTACs

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1196546-33-4