GNF-8625

• Description :

  GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC; Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gnf-8625.html

• Smiles :

  FC1=CC=CC([C@@H]2N(CCC2)C3=NN4C(C5=CC=CC(C6=CC=NC(N7CCC(CC7)O)=C6)=N5)=CN=C4C=C3)=C1

• Molecular Formula :

  C31H30FN7O

• Molecular Weight :

  535.61

• References & Citations :

  [1]Selectively targeting tropomyosin receptor kinase a (TRKA) via PROTACs

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1196546-33-4]