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GNF-2-deg

CAT: 0931-T210186-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210186-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PROTACs, Anti-infection
Related Pathways
Microbiology/Virology, PROTAC
Bioactivity
GNF-2-deg is a PROTAC degrader that targets the envelope protein of the dengue virus (DENV E protein), achieving a DC50 of 0.83 μM. It inhibits viral entry by preventing membrane fusion mediated by the E protein and demonstrates antiviral activity against DENV 2 through protein degradation, with an EC90 of 3.5 μM. Additionally, GNF-2-deg shows antiviral efficacy against ZIKV, JEV, WNV, and YFV, with EC90 values ranging from 1.96 to 7.79 μM.
Molecular Formula
C37H33F3N6O9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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