MQA-P

MQA-P

• UNSPSC Description: MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO- (λem=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λem>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images[1].
• Target Antigen: Fluorescent Dye
• Type: Dye Reagents
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/mqa-p.html
• Solubility: 10 mM in DMSO
• Smiles: CN(C1=CC=C(C=C1)/C=C/C=C/C2=CC=[N+](C3=C2C=CC=C3)CC4=CC=C(C=C4)OP(C5=CC=CC=C5)(C6=CC=CC=C6)=O)C.[Br-]
• Molecular Weight: 687.60
• References & Citations: [1]Li Fan, et al. Multifunctional Fluorescent Probe for Simultaneous Detection of ONOO-, Viscosity, and Polarity and Its Application in Ferroptosis and Cancer Models. Anal Chem. 2023 Apr 4;95(13):5780-5787.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported