JPE-1375

• CAS Number :

  1254036-23-1

• Target :

  Complement System|||Others

• Related Pathways :

  Others|||Immunology/Inflammation

• Bioactivity :

  JPE-1375, a complement C5a receptor 1 (C5aR1) antagonist, effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice, making it useful for autoimmune and inflammatory disease research [1].

• Smiles :

  C([C@@H](NC([C@H](CC1=CC=CC=C1)NC(=O)[C@@H]2CC(=O)NC(=O)N2)=O)CCCN)(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(F)C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N)=O)=O)=O)CCC(C)C)=O)CCC3

• Molecular Formula :

  C49H63FN10O9

• Molecular Weight :

  955.08

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C