JPE-1375

CAT: 0931-T74650Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T74650Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1254036-23-1
Target
Complement System|||Others
Related Pathways
Others|||Immunology/Inflammation
Bioactivity
JPE-1375, a complement C5a receptor 1 (C5aR1) antagonist, effectively inhibits polymorphonuclear leukocyte mobilization (EC50=6.9 µM) and reduces TNF levels (EC50=4.5 µM) in mice, making it useful for autoimmune and inflammatory disease research [1].
Smiles
C([C@@H](NC([C@H](CC1=CC=CC=C1)NC(=O)[C@@H]2CC(=O)NC(=O)N2)=O)CCCN)(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(F)C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N)=O)=O)=O)CCC(C)C)=O)CCC3
Molecular Formula
C49H63FN10O9
Molecular Weight
955.08
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS5816588JPE-1375
A24484-50JPE-1375 50mg
A24484-100JPE-1375 100mg
A24484-5JPE-1375 5mg
A24484-10JPE-1375 10mg
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A19190-100TUG-1375 100mg
A19190-5TUG-1375 5mg
A19190-500TUG-1375 500mg

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