HS-27

CAT: 0804-HY-130851-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-130851-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
HS-27, a fluorescently-tethered Hsp90 inhibitor, assays surface Hsp90 expression on intact tissue specimens. HS-27 is made up of the core elements of SNX-5422, an Hsp90 inhibitor, tethered via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC), that binds to ectopically expressed Hsp90. HS-27 has potential use in a see-and-treat paradigm in breast cancer[1].
CAS Number
[1562024-11-6]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hs-27.html
Purity
98.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC=C(N2N=C(C)C3=C2CC(C)(C)CC3=O)C=C1NCCCOCCOCCOCCOCCOCCCNC(NC4=CC5=C(C6(C7=C(OC8=C6C=CC(O)=C8)C=C(O)C=C7)OC5=O)C=C4)=S
Molecular Formula
C52H60N6O12S
Molecular Weight
993.13
References & Citations
[1]Crouch BT, et al. Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer. Sci Rep. 2019 Mar 5;9 (1) :3461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

Related Products

CatalogName
HY-15868-01HS-173
HY-129156-01HS-1793
HY-122878HS-131
HY-114349-01HS-1371
HY-157181Hal-HS
HY-157084HS-291
HY-123486HS-438
HY-134911-01HS-243
HY-147141-01HS-276
HY-P5622Hs-1

Alternative Products

CatalogName
M33552-01HS-27
MBS3603442-01HS-1371
MBS3612262-01HS 024
M28489-01HS-243
10HSC10BHs-CRP
ARI0063HS-5
ARC0316Hs 695T
ARC0311Hs 445
ARP0996Hs 578Bst
MBS3846775-01HS-1793

Popular Products