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HS-345

CAT: 0804-HY-164483Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-164483Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HS-345 is a TrkA/Ak inhibitor with significant anti-pancreatic cancer effects. HS-345 inhibits the growth and proliferation of pancreatic cancer cells by targeting the TrkA/Akt signaling pathway, while also inducing apoptosis. Additionally, HS-345 suppresses blood vessel formation by decreasing the expression of HIF-1α and VEGF. HS-345 holds promise for research in pancreatic cancer[1].
CAS Number
[1462329-41-4]
UNSPSC
12352005
Target
Akt; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hs-345.html
Smiles
O=S(C1=CC(C2=CN=C(NC=C3C4=CC=NC=C4)C3=C2)=CN=C1N)(N(C)C)=O
Molecular Formula
C19H18N6O2S
Molecular Weight
394.45
References & Citations
[1]Seo JH, et al. Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer. Cancer Lett. 2013 Sep 28;338 (2) :271-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA

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