HS-345

• Description :

  HS-345 is a TrkA/Ak inhibitor with significant anti-pancreatic cancer effects. HS-345 inhibits the growth and proliferation of pancreatic cancer cells by targeting the TrkA/Akt signaling pathway, while also inducing apoptosis. Additionally, HS-345 suppresses blood vessel formation by decreasing the expression of HIF-1α and VEGF. HS-345 holds promise for research in pancreatic cancer[1].

• UNSPSC :

  12352005

• Target :

  Akt; Trk Receptor

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hs-345.html

• Smiles :

  O=S(C1=CC(C2=CN=C(NC=C3C4=CC=NC=C4)C3=C2)=CN=C1N)(N(C)C)=O

• Molecular Formula :

  C19H18N6O2S

• Molecular Weight :

  394.45

• References & Citations :

  [1]Seo JH, et al. Anti-cancer effect of HS-345, a new tropomyosin-related kinase A inhibitor, on human pancreatic cancer. Cancer Lett. 2013 Sep 28;338 (2) :271-81.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TrkA

• CAS Number :

  [1462329-41-4]