HS-131

• Description:

  HS-131, a near infrared dye tethered Hsp90 inhibitor, is able to detect oncogene-driven breast cancers, including multiple different molecular subtypes of human breast cancers[1].

• UNSPSC:

  12171500

• Target:

  HSP

• Type:

  Dye Reagents

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hs-131.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NN(C2=CC(NCCCOCCOCCOCCOCCOCCCNCC3=CC=C(C=C3)C(/C=C/C4=[N+](C5=CC=CC=C5C4(C)C)CCCCS(=O)([O-])=O)=C\C=C6N(C7=CC=CC=C7C\6(C)C)CCCCS(=O)(O)=O)=C(C=C2)C(N)=O)C8=C1C(CC(C)(C8)C)=O

• Molecular Formula:

  C71H95N7O13S2

• Molecular Weight:

  1318.68

• References & Citations:

  [1]Takuya Osada, et al. In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior. Clin Cancer Res. 2017 Dec 15;23 (24) :7531-7542.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [2084850-40-6]