HS-291

• UNSPSC Description:

  HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb[1].

• Target Antigen:

  Bacterial; ROS Kinase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/hs-291.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CCC1=C(N2)/C=C3C(CCC(OC)=O)=C(C)C(/C=C4N/C(C(C)=C\4C=C)=C\C(C5=CC=C([C@H]([C@]5/6C)C(OC)=O)C(OC)=O)=NC6=C/C2=C1C)=N/3)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC7=CC=C(N8C(NN=C8C9=C(O)C=C(O)C(C(C)C)=C9)=S)C=C7)=O.CC(CCC%10=C%11NC(/C=C(N=C(/C=C(N/C%12=C\C(C(C)=C/%13CCC(ONCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC(C=C%14)=CC=C%14N%15C(C(C=C(C(O)=C%16)C(C)C)=C%16O)=NNC%15=S)=O)=O)=NC%13=C/%11)/C(C)=C%12C=C)C%17=CC=C(C(OC)=O)[C@H]%18C(OC)=O)/[C@@]%17%18C)=C%10C)=O

• Molecular Weight:

  2961.44

• References & Citations:

  [1]Carlson DL, et al. Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development. Cell Chem Biol. 2023 Nov 1:S2451-9456(23)00340-9.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported