HS-291

CAT: 0804-HY-157084Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157084Size:1 Each
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Description
HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb) . HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin) .HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb[1].
UNSPSC
12352005
Target
Bacterial; ROS Kinase
Type
Reference compound
Related Pathways
Anti-infection; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hs-291.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=C(N2)/C=C3C(CCC(OC)=O)=C(C)C(/C=C4N/C(C(C)=C\4C=C)=C\C(C5=CC=C([C@H]([C@]5/6C)C(OC)=O)C(OC)=O)=NC6=C/C2=C1C)=N/3)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC7=CC=C(N8C(NN=C8C9=C(O)C=C(O)C(C(C)C)=C9)=S)C=C7)=O.CC(CCC%10=C%11NC(/C=C(N=C(/C=C(N/C%12=C\C(C(C)=C/%13CCC(ONCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC(C=C%14)=CC=C%14N%15C(C(C=C(C(O)=C%16)C(C)C)=C%16O)=NNC%15=S)=O)=O)=NC%13=C/%11)/C(C)=C%12C=C)C%17=CC=C(C(OC)=O)[C@H]%18C(OC)=O)/[C@@]%17%18C)=C%10C)=O
Molecular Formula
C156H194N18O36S2
Molecular Weight
2961.44
References & Citations
[1]Carlson DL, et al. Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development. Cell Chem Biol. 2023 Nov 1:S2451-9456 (23) 00340-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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