HS-1371

• Description:

  HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1].

• Product Name Alternative:

  Ro 40-7591, Hydroxytolbutamide-d9

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/HS-1371.html

• Purity:

  99.86

• Solubility:

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles:

  CC1=CC=C (OC2=CC=NC3=CC (C4=CN (C5CCNCC5) N=C4) =CC=C23) C=C1

• Molecular Formula:

  C24H24N4O

• Molecular Weight:

  384.47

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50 (9) :125.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2158197-70-5