HS-1371

• Description :

  HS-1371 is a potent and ATP-competitive receptor-interacting protein kinase 3 (RIP3) inhibitor with an IC50 of 20.8 nM[1].

• Product Name Alternative :

  Ro 40-7591, Hydroxytolbutamide-d9

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  RIP kinase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/HS-1371.html

• Purity :

  99.86

• Solubility :

  DMSO : 16.67 mg/mL (ultrasonic)

• Smiles :

  CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1

• Molecular Formula :

  C24H24N4O

• Molecular Weight :

  384.47

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Park HH, et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp Mol Med. 2018 Sep 20;50 (9) :125.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2158197-70-5]