HS-345

• CAS Number :

  1462329-41-4

• Target :

  Akt|||Trk receptor

• Related Pathways :

  Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors

• Bioactivity :

  HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis) . Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1? and VEGF. It holds promise for use in pancreatic cancer research.

• Smiles :

  O=S(=O)(C=1C=C(C=NC1N)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)N(C)C

• Molecular Formula :

  C19H18N6O2S

• Molecular Weight :

  394.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C