HS-345

• Target:

  Akt|||Trk receptor

• Related Pathways:

  Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors

• Bioactivity:

  HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis) . Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1? and VEGF. It holds promise for use in pancreatic cancer research.

• Smiles:

  O=S (=O) (C=1C=C (C=NC1N) C2=CN=C3NC=C (C=4C=CN=CC4) C3=C2) N (C) C

• Molecular Formula:

  C19H18N6O2S

• Molecular Weight:

  394.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1462329-41-4