HS-243

• Description:

  HS-243 is a potent and selective IRAK-4 and IRAK-1 inhibitor, with IC50 values of 20 and 24 nM. HS-243 shows minimal TAK1 (transforming growth factor β-activated kinase 1) inhibition activity, with a IC50 of 0.5 μM. HS-243 shows anti-inflammatory and anticancer activity[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  CDK; IRAK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/hs-243.html

• Purity:

  99.95

• Solubility:

  DMSO : 41.67 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=NC2=CC=CC=C2N1CCC)C3=CC=CC([N+]([O-])=O)=C3

• Molecular Formula:

  C17H16N4O3

• Molecular Weight:

  324.33

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Scarneo SA, et al. A highly selective inhibitor of interleukin-1 receptor-associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase. J Biol Chem. 2020 Feb 7;295 (6) :1565-1574.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CLK; IRAK1; IRAK4

• CAS Number:

  [848249-10-5]