Nrf2 degrader 1

Nrf2 degrader 1

• CAS Number: 3025286-00-1
• UNSPSC Description: Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively[1].
• Target Antigen: Keap1-Nrf2; PROTACs
• Type: Reference compound
• Related Pathways: NF-κB;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nrf2-degrader-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1NC(C(N2C(C(C(NCCOCCOC3=CC(CC(NC4=NC(C5=CC=C(N(C(C6=C(C)C=CC=C6)=O)CC7)C7=C5)=C(C)S4)=O)=CC=C3)=CC=C8)=C8C2=O)=O)CC1)=O
• Molecular Weight: 826.92
• References & Citations: [1]John Edwin Munroe, et al. Nrf2 protein degraders. WO2024006742A2.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported