Ro24-7429

• Description:

  Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; HIV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ro24-7429.html

• Concentration:

  10mM

• Purity:

  99.85

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  CNC1=NC2=CC=C(Cl)C=C2C(C3=CC=CN3)=NC1

• Molecular Formula:

  C14H13ClN4

• Molecular Weight:

  272.73

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169 (1) :40-6.|[2]Michael O'Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191 (7) :1193-1208.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HIV-1

• CAS Number:

  [139339-45-0]