DS-7423

CAT: 0804-HY-124036-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-124036-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].

CAS Number

1222104-37-1

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ds-7423.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(N1[C@H](C)CN(C2=NC3=C(N4CCOCC4)N=C(C5=CN=C(N)N=C5)N=C3N2CC(F)(F)F)CC1)=O

Molecular Formula

C22H27F3N10O2

Molecular Weight

520.51

References & Citations

[1]Katsutoshi Oda, et al. Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies. J Obstet Gynaecol Res. 2016 Jul;42 (7) :757-62.|[2]Tomoko Kashiyama, et al. Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. PLoS One. 2014 Feb 4;9 (2) :e87220.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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HY-144401-01	DS-3801b
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Alternative Products

Catalog	Name
BA8718-10	DS-7423
2332339	WSE-7423 EzBactYeastCrusher
C18240	DS-1001b (DS 1001)
10050-AAT	Stain-All CAS 7423-31-6
BA7852-50	DS-1001b
BA4837-50	DS-437
BA4774-1	DS-9300
BD181252-01	DS 16570511
T9901A-1690-01	DS-1501
T89077-01	DS-1093a

DS-7423

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