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RO27-3225 (TFA)

CAT: 0804-HY-P2242A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2242A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO27-3225 TFA is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 TFA shows ~30-fold selectivity for MC4R over MC3R. RO27-3225 TFA has neuroprotective and anti-inflammatory effects[1][2][3].
CAS Number
1373926-49-8
UNSPSC
12352209
Target
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro27-3225-tfa.html
Purity
99.77
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CCCC(N[C@@H](CC1=CN=CN1)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N(C)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C39H52N12O6.xC2HF3O2
Molecular Weight
784.91 (free base)
References & Citations
[1]Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150 (5) :595-603.|[2]Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.|[3]Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20 (9) :3442-8.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MC4R

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