Colibactin 742

• Description:

  Colibactin 742, a stable colibactin derivative, induces DNA interstrand-cross-links, activation of the Fanconi Anemia DNA repair pathway, and G2/M arrest.

• UNSPSC:

  12352005

• Target:

  DNA Alkylator/Crosslinker

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/colibactin-742.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCC1=NC(CCC2=NC(C3(O)CNC(C3C4=C(C5=N[C@@H](C)CC5)C(N[C@]46CC6)=O)=O)=CS2)=CS1)CC([C@@]7(CC7)N8)=C(C9=N[C@@H](C)CC9)C8=O

• Molecular Formula:

  C37H42N8O5S2

• Molecular Weight:

  742.91

• References & Citations:

  [1]Wernke KM, et al. Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies. J Am Chem Soc. 2021 Sep 29;143 (38) :15824-15833.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2916559-62-9]