Colibactin 742

• Description :

  Colibactin 742, a stable colibactin derivative, induces DNA interstrand-cross-links, activation of the Fanconi Anemia DNA repair pathway, and G2/M arrest.

• CAS Number :

  [2916559-62-9]

• UNSPSC :

  12352005

• Target :

  DNA Alkylator/Crosslinker

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/colibactin-742.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCC1=NC(CCC2=NC(C3(O)CNC(C3C4=C(C5=N[C@@H](C)CC5)C(N[C@]46CC6)=O)=O)=CS2)=CS1)CC([C@@]7(CC7)N8)=C(C9=N[C@@H](C)CC9)C8=O

• Molecular Formula :

  C37H42N8O5S2

• Molecular Weight :

  742.91

• References & Citations :

  [1]Wernke KM, et al. Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies. J Am Chem Soc. 2021 Sep 29;143 (38) :15824-15833.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported