RO27-3225

CAT: 0804-HY-P2242Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P2242Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO27-3225 is potent and selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 1 nM and 8 nM for MC4R and MC1R, respectively. RO27-3225 shows 30-fold selectivity for MC4R over MC3R. RO27-3225 has neuroprotective and anti-inflammatory effects[1][2][3].
CAS Number
[274682-89-2]
UNSPSC
12352209
Target
Melanocortin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
CCCC(N[C@@H](CC1=CN=CN1)C(N[C@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N(C)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O)=O)=O)=O
Molecular Formula
C39H52N12O6
Molecular Weight
784.91
References & Citations
[1]Benoit SC, et al. A novel selective melanocortin-4 receptor agonist reduces food intake in rats and mice without producing aversive consequences. J Neurosci. 2000 May 1;20 (9) :3442-8.|[2]Giuliani D, et al. Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol. 2007 Mar;150 (5) :595-603.|[3]Zhang Y, et al. Effects of RO27-3225 on neurogenesis, PDGFRβ+ cells and neuroinflammation after cerebral infarction. Int Immunopharmacol. 2020 Feb 11;81:106281.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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