NP3-742

• Description:

  NP3-742 is an orally active NLRP3 inhibitor that binds to the NLRP3 NACHT domain. NP3-742 inhibits IL-1β release with IC50s of 6 nM and 47 nM in both the cellular and whole blood assays, respectively. NP3-742 is highly selective against a panel of more than 50 enzymes, receptors and sodium and calcium channels. NP3-742 can be used for the study of gout, cardiovascular disease or osteoarthritis[1].

• Target:

  Interleukin Related; NOD-like Receptor (NLR)

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease; Metabolic Disease

• Smiles:

  CC1=CC2=C(N1)N=C(C=C2)C3=C(C=C(N=N3)N[C@@H]4CCCN(C4)C)C

• Molecular Formula:

  C19H24N6

• Molecular Weight:

  336.43

• References & Citations:

  [1]Velcicky J, et al. Discovery of NP3-742: A Structurally Diverse NLRP3 Inhibitor Identified through an Unusual Phenol Replacement. J Med Chem. 2025;68 (21) :23532-23553.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IL-1; NLRP3