GNF-1331

• Description :

  GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM) . GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model[1].

• UNSPSC :

  12352005

• Target :

  Porcupine; Wnt

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/gnf-1331.html

• Purity :

  99.84

• Smiles :

  O=C(CSC1=NN=C(N1CCC)C2=CC=NC=C2)NC3=NC4=CC=C(C=C4S3)OC

• Molecular Formula :

  C20H20N6O2S2

• Molecular Weight :

  440.54

• References & Citations :

  [1]Dai Cheng, et al. "Discovery of pyridinyl acetamide derivatives as potent, selective, and orally bioavailable porcupine inhibitors." ACS medicinal chemistry letters 7.7 (2016) : 676-680.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [603101-22-0]