GNF-1331

CAT: 0804-HY-123334-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-123334-01Size:1 mg
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Description
GNF-1331 (compound 19) is a potent, selective and orally bioavailable porcupine inhibitor (IC50=12 nM) . GNF-1331 blocks Wnt ligand secretion and subsequent Wnt signaling activity, and induces significant antitumor effects in the mouse MMTV-WNT1 xenograft tumor model[1].
CAS Number
[603101-22-0]
UNSPSC
12352005
Target
Porcupine; Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gnf-1331.html
Purity
99.84
Smiles
O=C(CSC1=NN=C(N1CCC)C2=CC=NC=C2)NC3=NC4=CC=C(C=C4S3)OC
Molecular Formula
C20H20N6O2S2
Molecular Weight
440.54
References & Citations
[1]Dai Cheng, et al. "Discovery of pyridinyl acetamide derivatives as potent, selective, and orally bioavailable porcupine inhibitors." ACS medicinal chemistry letters 7.7 (2016) : 676-680.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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