Products for Research Use Only
RegisterLogin

GNF-7

CAT: 0804-HY-10943-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-10943-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies[1][2][3].
CAS Number
839706-07-9
UNSPSC
12352005
Hazard Statement
H301
Target
Ack1; Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GNF-7.html
Purity
99.70
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Molecular Formula
C28H24F3N7O2
Molecular Weight
547.53
Precautions
H301
References & Citations
[1]Choi HG, et al. A type-II kinase inhibitor capable of inhibiting the T315I "gatekeeper" mutant of Bcr-Abl. J Med Chem. 2010 Aug 12;53 (15) :5439-48.|[2]Lu X, et al. Hybrid pyrimidine alkynyls inhibit the clinically resistance related Bcr-Abl (T315I) mutant. Bioorg Med Chem Lett. 2015 Sep 1;25 (17) :3458-63.|[3]Cho, H., et al. First SAR study for overriding NRAS mutant driven acute myeloid leukemia. Journal of Medicinal Chemistry.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15738-01GNF-5
HY-118271GNF-8625
HY-123334-01GNF-1331
HY-160478GNF-6
HY-100408-01GNF-6231
HY-11007-01GNF-2
HY-13491-01GNF-5837
HY-161804GNF-2-deg
HY-11007R-01GNF-2 (Standard)
HY-100408RGNF-6231 (Standard)

Alternative Products

CatalogName
B1139-5GNF-7
451395-01GNF 7
A15887-10GNF-7 10mg
A15887-5GNF-7 5mg
A15887-100GNF-7 100mg
A15887-50GNF-7 50mg

Popular Products