CB2R/FAAH modulator-3

• Description :

  CB2R/FAAH modulator-3 (compound 27) is a dual targeting modulator that acts as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R/FAAH modulator-3 are 20.1 and 67.6 nM for CB2R and CB1R, respectively, and the IC50 value for FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used in studies related to cancer, deleterious inflammatory cascades occurring in neurodegenerative diseases, and COVID-19 infection[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319

• Target :

  Cannabinoid Receptor; FAAH

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cb2r-faah-modulator-3.html

• Purity :

  99.71

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(OCCCCC)C=CC=C1)N[C@@]2(C3)CC4CC3CC(C4)C2

• Molecular Formula :

  C22H31NO2

• Molecular Weight :

  341.49

• Precautions :

  P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

• References & Citations :

  [1]Francesca Intranuovo, et al. Development of N- (1-Adamantyl) benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66 (1) :235-250.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CB1; CB2

• CAS Number :

  [2876918-67-9]