FAAH/MAGL-IN-3

• UNSPSC Description:

  FAAH/MAGL-IN-3 (Compound 10) is an irreversible fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) dual inhibitor with IC50 values of 179 and 759 nM against FAAH and MAGL, respectively. FAAH/MAGL-IN-3 shows low PAMPA (Parallel Artificial Membrane Permeability Assay) permeability[1].

• Target Antigen:

  FAAH; MAGL

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/faah-magl-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCC1=CC=C(C=C1)S(=O)(N2CCN(CC2)C(OC3=CC=C(C=C3)[N+]([O-])=O)=O)=O

• Molecular Weight:

  447.50

• References & Citations:

  [1]Alan Fulp, et al. Design and synthesis of endocannabinoid enzyme inhibitors for ocular indications. Bioorg Med Chem Lett. 2022 Jul 15;68:128763.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2848719-34-4