CB2R PAM

• Description:

  CB2R PAM is an orally active cannabinoid type-2 receptors (CB2Rs) positive allosteric modulator. CB2R PAM displays antinociceptive activity in vivo in an experimental mouse model of neuropathic pain[1].

• UNSPSC:

  12352005

• Target:

  Cannabinoid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cb2r-pam.html

• Concentration:

  10mM

• Purity:

  98.09

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  FC1=CC=C (CN2C (C (NC (C3CCCCCC3) =O) =C (C) C (Br) =C2) =O) C=C1

• Molecular Formula:

  C21H24BrFN2O2

• Molecular Weight:

  435.33

• References & Citations:

  [1]Gado F, et al. Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. J Med Chem. 2019;62 (1) :276-287.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CB2

• CAS Number:

  2244579-87-9