CB2R/FAAH modulator-1

• Description :

  CB2R/FAAH modulator-1 is a cannabinoid type 2 receptor (CB2R) full agonist with Kis of 14.8 nM and 241.3 nM for CB2R and CB1R, respectively. CB2R/FAAH modulator-1 is a fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 4 μM. CB2R/FAAH modulator-1 decreases pro-inflammatory and increases anti-inflammatory cytokines production[1].

• UNSPSC :

  12352005

• Target :

  Cannabinoid Receptor; FAAH

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cb2r-faah-modulator-1.html

• Purity :

  99.14

• Solubility :

  DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=C(OCC2=CC=CC=C2)C=CC=C1)NC3(C[C@H](C4)C5)C[C@@H]4C[C@@H]5C3

• Molecular Formula :

  C24H27NO2

• Molecular Weight :

  361.48

• References & Citations :

  [1]Francesca Intranuov, et al. Development of N- (1-Adamantyl) benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66 (1) :235-250.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CB1; CB2

• CAS Number :

  [928892-60-8]