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AChE-IN-72

CAT: 0804-HY-163909Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163909Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-72 (Compound 13a) is an inhibitor for acetylcholinesterase (AChE) with an IC50 of 0.59 μM. AChE-IN-72 inhibits BChE with an IC50 of 5.02 μM. AChE-IN-72 exhibits radical scavenging with IC50 of 5.88 μM. AChE-IN-72 exhibits iron-chelating property, inhibits Aβ1−42 aggregation, and inhibits NLRP3 inflammasome activation. AChE-IN-72 ameliorates memory impairment in Betaine -induced AD mouse model. AChE-IN-72 is blood-brain barrier (BBB) penetrable[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-72.html
Smiles
O=C(N1CCN(CC2=C3C=CC=NC3=C(O)C=C2)CC1)/C=C/C4=CC=C(O)C(OC)=C4
Molecular Formula
C24H25N3O4
Molecular Weight
419.47
References & Citations
[1]Singh G, et al., Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer's Disease. ACS Chem Neurosci. 2024 Aug 7;15 (15) :2756-2778.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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