AChE-IN-72

CAT: 0931-T89586-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T89586-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Cholinesterase (ChE)
Related Pathways
Neuroscience
Bioactivity
AChE-IN-72 (Compound 13a) serves as an inhibitor of acetylcholinesterase (AChE) with an IC50 value of 0.59 ?M and also inhibits butyrylcholinesterase (BChE) with an IC50 of 5.02 ?M. Moreover, this compound exhibits radical scavenging activity, demonstrated by an IC50 of 5.88 ?M, and exhibits iron-chelating properties that inhibit the aggregation of A?1-42 and the activation of the NLRP3 inflammasome. AChE-IN-72 has shown to ameliorate memory impairments in a Betaine-induced Alzheimers disease (AD) mouse model and possesses blood-brain barrier (BBB) permeability.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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