BMS-935177

• Description:

  BMS-935177 is a potent and selective reversible inhibitor of Bruton’s tyrosine kinase (Btk) with an IC50 of 3 nM.

• UNSPSC:

  12352005

• Target:

  Btk

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/BMS-935177.html

• Purity:

  99.11

• Solubility:

  DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(C1=CC=C(C2=CC=CC(N3C=NC4=C(C=CC=C4)C3=O)=C2C)C5=C1NC6=C5C=CC(C(C)(O)C)=C6)N

• Molecular Formula:

  C31H26N4O3

• Molecular Weight:

  502.56

• References & Citations:

  [1]De Lucca GV, et al. Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK) : Structure-Activity Relationships Leading to the Identification of 7- (2-Hydroxypropan-2-yl) -4-[2-methyl-3- (4-oxo-3,4-dihydroquinazolin-3-yl) phenyl]-9H-carbazole-1-carboxamide (BMS-935177) . J Med Chem. 2016 Sep 8;59 (17) :7915-35.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1231889-53-4]