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BMS-935177

CAT: 0804-HY-101793-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101793-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-935177 is a potent and selective reversible inhibitor of Bruton’s tyrosine kinase (Btk) with an IC50 of 3 nM.
CAS Number
1231889-53-4
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BMS-935177.html
Purity
99.11
Solubility
DMSO : 75 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C2=CC=CC(N3C=NC4=C(C=CC=C4)C3=O)=C2C)C5=C1NC6=C5C=CC(C(C)(O)C)=C6)N
Molecular Formula
C31H26N4O3
Molecular Weight
502.56
References & Citations
[1]De Lucca GV, et al. Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK) : Structure-Activity Relationships Leading to the Identification of 7- (2-Hydroxypropan-2-yl) -4-[2-methyl-3- (4-oxo-3,4-dihydroquinazolin-3-yl) phenyl]-9H-carbazole-1-carboxamide (BMS-935177) . J Med Chem. 2016 Sep 8;59 (17) :7915-35.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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