PROTAC BRAF-V600E degrader-1

• UNSPSC Description:

  PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with Kd value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth[1].

• Target Antigen:

  PROTACs; Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-braf-v600e-degrader-1.html

• Smiles:

  CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(C(CCOCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)CC5)C)=CC=C42)=C1F)=O

• Molecular Weight:

  1001.07

• References & Citations:

  [1]Han XR, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem. 2020 Apr 23;63(8):4069-4080.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2417296-84-3