PROTAC BRAF-V600E degrader-2

PROTAC BRAF-V600E degrader-2

• CAS Number: 2417296-82-1
• UNSPSC Description: PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].
• Target Antigen: PROTACs; Raf
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-braf-v600e-degrader-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCC1=CC=C(C2=CN=C(NC=C3C(C4=C(F)C=CC(NS(=O)(CCC)=O)=C4F)=O)C3=C2)C=C1)CCCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5
• Molecular Weight: 839.86
• References & Citations: [1]Xiao-Ran Han, et al. Discovery of Selective Small Molecule Degraders of BRAF-V600E. J Med Chem. 2020 Apr 23;63(8):4069-4080.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported