PROTAC MEK1 Degrader-1

PROTAC MEK1 Degrader-1

• CAS Number: 2671004-41-2
• UNSPSC Description: PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells[1].
• Target Antigen: ERK; MEK; PROTACs
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;PROTAC;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-mek1-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(NC(C=C(C(N1C)=O)C)=C1NC2=C(C=C(C=C2)I)F)(C3=CC=C(C=C3)CCC(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)=O)=O)=O)=O
• Molecular Weight: 1201.17
• References & Citations: [1]Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported