PROTAC Chk1 degrader-1

• UNSPSC Description:

  PROTAC Chk1 degrader-1 (Compound PROTAC-2 ) is a potent PROTAC-targeted degrader of Chk1 with a DC50 of 1.33 μM. PROTAC Chk1 degrader-1 can be used in cancer research[1].

• Target Antigen:

  Checkpoint Kinase (Chk); PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-chk1-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CCC1=CC=C(NC2=NC(C(NCC3=CN(CCOCCOCCNC(COC4=C5C(C(N(C6C(NC(CC6)=O)=O)C5=O)=O)=CC=C4)=O)N=N3)=O)=CC(NC7=NNC(C8CC8)=C7)=N2)C=C1

• Molecular Weight:

  900.90

• References & Citations:

  [1]Chowdhury S R, et al. Development of a PROTAC Targeting Chk1[J]. bioRxiv, 2024: 2023.12. 30.573733.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2597167-34-3