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BRAF V600E/CRAF-IN-1

CAT: 0804-HY-146442Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146442Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BRAF V600E/CRAF-IN-1 (Compound 8b) is a potent inhibitor of BRAF V600E/CRAF. BRAF V600E/CRAF-IN-1 triggers apoptosis and cell cycle arrest at G0/G1 phase in HCT-116 colon cancer cell. BRAF V600E/CRAF-IN-1 has the potential for the research of cancer diseases[1].
CAS Number
2499499-56-6
UNSPSC
12352005
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/braf-v600e-craf-in-1.html
Solubility
10 mM in DMSO
Smiles
COC1=C2C=CC(NC3=CC(NC(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)=O)=CC=C3)=NC2=CC=C1
Molecular Formula
C25H17F6N3O2
Molecular Weight
505.41
References & Citations
[1]El-Damasy AK, et al. 2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments. Eur J Med Chem. 2020 Dec 15;208:112756.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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