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MDL-27531

CAT: 0804-HY-W975902Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W975902Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDL-27531 acts functionally like a glycine agonist. MDL-27531 selectively reduces hindlimb contractions. MDL-27531 selectively reverses strychnine-induced seizures in mice. MDL-27531 inhibits pentylenetetrazol-induced seizures with an ED50 of 55 mg/kg. MDL-27531 promotes the binding of benzodiazepine antagonist Ro 15-1788 to cerebral cortex of mice without changing GABA levels. MDL-27531 can be studied in research on reflex control dysfunction[1][2].
CAS Number
116850-44-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Glycine Receptor (GlyR)
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=S(=O)(C1=NN=C(C=2C=CC=CC2)N1C)C
Molecular Formula
C10H11N3O2S
Molecular Weight
237.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Kehne, J. H., et al., (1992) . MDL 27,531 selectively reverses strychnine-induced seizures in mice. British journal of pharmacology, 106 (4), 910-916.|[2]Kehne, J. H., et al., (1992) . MDL 27,531 reduces spontaneous hindlimb contractions in rats with chronic transections of the spinal cord. Neuroscience letters, 147 (1), 101-105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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