MDL 27032

• Description :

  MDL 27032 is an active site-directed inhibitor of protein kinase C (PKC) and cAMP-dependent protein kinase (PKA) with Ki values of 24 and 14.3μM. MDL 27032 can relaxe vascular smooth muscle and can be used as vasodilator[1].

• CAS Number :

  [110124-55-5]

• UNSPSC :

  12352005

• Target :

  PKA; PKC

• Related Pathways :

  Epigenetics; Stem Cell/Wnt; TGF-beta/Smad

• Field of Research :

  Cardiovascular Disease

• Smiles :

  CCCC(N1)=C(C2=CC=NC=C2)OC1=O

• Molecular Formula :

  C11H12N2O2

• Molecular Weight :

  204.23

• References & Citations :

  [1]Robinson P J, et al. MDL 27,032 [4-propyl-5- (4-pyridinyl) -2 (3H) -oxazolone], an active site-directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle[J]. The Journal of pharmacology and experimental therapeutics, 1990, 255 (3) : 1392-1398.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported