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MDL-800

CAT: 0804-HY-119376-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119376-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MDL-800 is an allosteric and selective SIRT6 activator. MDL-800 increases SIRT6 deacetylation activity with an EC50 of 10.3 µM[1].
CAS Number
2275619-53-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sirtuin
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.11
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
ClC1=CC(S(NC2=CC=C(S(NC3=CC(Br)=C(F)C=C3C)(=O)=O)C(C(OC)=O)=C2)(=O)=O)=CC(Cl)=C1
Molecular Formula
C21H16BrCl2FN2O6S2
Molecular Weight
626.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Huang Z, et al. Identification of a cellularly active SIRT6 allosteric activator. Nat Chem Biol. 2018 Dec;14 (12) :1118-1126.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT6