MDL 73811

• Description :

  MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Parasite

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O[C@@H]1[C@H](O)[C@@H](CN(C)C/C=C\CN)O[C@H]1N2C=NC3=C(N)N=CN=C32

• Molecular Formula :

  C15H23N7O3

• Molecular Weight :

  349.39

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Brockway AJ, et al. Synthesis and evaluation of analogs of 5'- (((Z) -4-amino-2-butenyl) methylamino) -5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. Bioorg Med Chem. 2017 Oct 15;25 (20) :5433-5440. |[2]Brockway AJ , et al. Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis (Stuttg) . 2016 Jul;48 (13) :2065-2068.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Trypanosoma

• CAS Number :

  [123642-27-3]