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MDL 73811

CAT: 0804-HY-112252Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-112252Size:1 Each
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Description
MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT[1].
CAS Number
[123642-27-3]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O[C@@H]1[C@H](O)[C@@H](CN(C)C/C=C\CN)O[C@H]1N2C=NC3=C(N)N=CN=C32
Molecular Formula
C15H23N7O3
Molecular Weight
349.39
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Brockway AJ, et al. Synthesis and evaluation of analogs of 5'- (((Z) -4-amino-2-butenyl) methylamino) -5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. Bioorg Med Chem. 2017 Oct 15;25 (20) :5433-5440. |[2]Brockway AJ , et al. Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis (Stuttg) . 2016 Jul;48 (13) :2065-2068.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Trypanosoma

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