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EGFR-IN-170

CAT: 0804-HY-175588Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175588Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-170 (Compound 5c) is an EGFR inhibitor with an IC50 of 5.17 μM. EGFR-IN-170 induces apoptosis by inhibiting Bcl2 expression and activating Bax expression with a significantly increased ratio of Bax/Bcl2. EGFR-IN-170 has potent anticancer activity and inhibits the cell growth of resistant lung cancer cells[1].
UNSPSC
12352100
Target
Apoptosis; Bcl-2 Family; EGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC(OC[C@H]1O[C@@H]([C@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)OC(C)=O)N2C=C(N=N2)COC3=CC(C4=CC=CC=C4C3=O)=O)=O
Molecular Formula
C27H27N3O12
Molecular Weight
585.52
References & Citations
[1]Singh K, et al. Design, synthesis, and molecular docking of 1,4-naphthoquinone based glycoconjugates as chiral glycohybrids targeting lung cancer. Bioorg Chem. 2025 Aug;163:108776.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2

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