GLPG-3221

CAT: 0804-HY-133013Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-133013Size:1 Each
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Description
GLPG-3221 is a potent, orally active corrector of CFTR (cystic fibrosis transmembrane conductance regulator), with an EC50 of 105 nM. GLPG-3221 can be uesd for the treatment of cystic fibrosis[1].
CAS Number
[2222264-64-2]
UNSPSC
12352005
Target
CFTR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/glpg-3221.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H]1N(C([C@@H]2CCCCO2)=O)[C@@H](C3=CC=CC=C3C)[C@@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[C@@H]1C(C)(C)C
Molecular Formula
C30H37F3N2O6
Molecular Weight
578.62
References & Citations
[1]Scanio MJC, et al.Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.ACS Med Chem Lett. 2019 Oct 31;10 (11) :1543-1548.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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