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L-Ascorbic acid (magnesium)

CAT: 0804-HY-B0166ESize: 1 EachDry Ice: NoHazardous: No
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Description
L-Ascorbic acid (L-Ascorbate) magnesium, an electron donor, is an endogenous antioxidant. L-Ascorbic acid selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition promoter and elastin production inhibitor. L-Ascorbic acid exhibits anticancer effects by generating reactive oxygen species (ROS) and selectively damaging cancer cells[1][2][3][4].
CAS Number
15431-40-0
Product Name Alternative
L-Ascorbate (magnesium) ; Vitamin C (magnesium)
UNSPSC
12352200
Hazard Statement
H315-H319-H320
Target
Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
95.0
Smiles
OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O.[0.5Mg2+]
Molecular Formula
C6H8O6.1/2Mg
Molecular Weight
187.27
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35. |[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27 (46) :12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75 (3) :173-82. |[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8 (1) :11372.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

Chemical Information

Magnesium Ascorbate

See also: EnBrace HR (FDA NDC: 64661-650) (component of).

CAS Number15431-40-0
PubChem CID54682511
IUPAC Namemagnesium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-olate)
Molecular FormulaC12H14MgO12
Molecular Weight374.54
Topological Polar Surface Area220
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count12
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity232
SMILES
C([C@@H]([C@@H]1C(=C(C(=O)O1)[O-])O)O)O.C([C@@H]([C@@H]1C(=C(C(=O)O1)[O-])O)O)O.[Mg+2]
InChI
InChI=1S/2C6H8O6.Mg/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1
InChIKey
AIOKQVJVNPDJKA-ZZMNMWMASA-L
Chemical Structure
2D Structure
2D structure of Magnesium Ascorbate
CAS: 15431-40-0
CID: 54682511
Formula: C12H14MgO12
MW: 374.54
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight374.54
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count12
Rotatable Bond Count4
Exact Mass374.0335676
Monoisotopic Mass374.0335676
Topological Polar Surface Area220 Ų
Heavy Atom Count25
Formal Charge0
Complexity232
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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