L-Ascorbic acid

L-Ascorbic acid

• CAS Number: 50-81-7
• UNSPSC Description: L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
• Target Antigen: Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species
• Type: Natural Products
• Related Pathways: Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/L-Ascorbic-acid.html
• Purity: 99.99
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
• Smiles: OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
• Molecular Weight: 176.12
• References & Citations: [1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.|[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372.|[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2.Anim Biotechnol. 2024 Nov;35(1):2404043.|Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208.|Antioxidants (Basel). 2024 May 27.|Biochem Biophys Res Commun. 2024 Mar 15, 149770.|Biomaterials. 2024 Aug 15:313:122756.|Biomed Pharmacother. September 2022, 113558.|Bioorg Chem. 2021, 105177.|Bioorg Chem. 2024 Mar 5:146:107261.|Biosci Rep. 2019 May 21;39(5):BSR20182137.|Cancer Cell Int. 2024 May 31;24(1):192.|Cancer Cell. 2024 Apr 8;42(4):682-700.e12.|Cell Biol Toxicol. 2021 Jul 20.|Cell Cycle. 2022 Nov 12;1-18.|Cell Host Microbe. 2024 Dec 12:S1931-3128(24)00444-X.|Clin Exp Pharmacol Physiol. 2024 Nov;51(11):e13923.|Cytotechnology. 02 October 2021.|Drug Chem Toxicol. 2023 Feb 23;1-9.|Eur J Med Chem. 2022 Jan 28;231:114151.|Fitoterapia. 2021 Jun 30;104984.|Food Funct. 2022 May 10;13(9):5089-5101.|Free Radic Biol Med. 2020 Feb 1;147:220-230.|Front Cell Dev Biol. 2022 Feb 10:10:810327.|Genes. 2024 Sep 13.|Int J Biol Macromol. 2023 Nov 17:127779.|iScience. 2024 Feb 5;27(3):109111.|IUBMB Life. 2024 Jul 16.|J Biol Chem. 2023 Nov 15:105462.|J Cell Mol Med. 2020 Apr;24(7):4212-4222.|J Cell Physiol. 2024 Feb 3.|J Mol Histol. 2024 May 27.|J Nat Prod. 2022 Jul 7.|J Neurosci Res. 2019 Dec;97(12):1689-1705. |J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913.|J Sex Med. 2018 Feb;15(2):136-147. |Mol Biol Rep. 2024 Mar 14;51(1):421.|Mol Med Rep. 2019 Dec; 20(6): 4933–4942.|Nat Immunol. 2022 Dec 21.|Nigerian Journal of Scientific Research. 18 (3): 2019.|Oxid Med Cell Longev. 2022 Jan 27;2022:7502632.|Redox Biol. 2022 Aug;54:102392.|Research Square Print. 2022 Aug.|Sci China Life Sci. 2018 Oct;61(10):1151-1167.|Environ Toxicol. 2021 Apr;36(4):520-529.|FASEB J. 2020 Sep;34(9):11474-11487.|Hematol Oncol. 2024 Jul;42(4):e3295.|J Afr Ass Physiol Sci. 7(1): 30-37, July 2019.|Mil Med Res. 2020 Nov 1;7(1):52.
• Shipping Conditions: Room Temperature
• Storage Conditions: RT, protect from light
• Clinical Information: Launched