L-Ascorbic acid-d2

L-Ascorbic acid-d2

• CAS Number: 82977-10-4
• UNSPSC Description: L-Ascorbic acid-d2 is the deuterium labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a colla
• Target Antigen: Apoptosis; Calcium Channel; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB;Others
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Metabolic Disease; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: OC([C@@]1([H])[C@H](C([2H])([2H])O)O)=C(O)C(O1)=O
• Molecular Weight: 178.14
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.;Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported