L-Ascorbic acid-13C

L-Ascorbic acid-13C

• CAS Number: 178101-88-7
• UNSPSC Description: L-Ascorbic acid-13C is the 13C-labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
• Target Antigen: Apoptosis; Calcium Channel; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB;Others
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Metabolic Disease; Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/l-ascorbic-acid-13c.html
• Purity: 99.90
• Solubility: 10 mM in DMSO
• Smiles: OC([C@@]([H])([C@@H](O)CO)O[13C]1=O)=C1O
• Molecular Weight: 177.12
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.|[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372.|[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2.|[6]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported