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L-Ascorbic acid (GMP Like)

CAT: 0804-HY-B0166GL-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0166GL-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].
CAS Number
50-81-7
Product Name Alternative
L-Ascorbate (GMP Like) ; Vitamin C (GMP Like)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)
Type
GMP Small Molecules
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-ascorbic-acid-gmp-like.html
Purity
99.88
Solubility
H2O : 100 mg/mL (ultrasonic) |DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O
Molecular Formula
C6H8O6
Molecular Weight
176.12
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27 (46) :12577-83.|[2]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75 (3) :173-82.|[3]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8 (1) :11372.|[4]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5 (1) :2.|[5]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35.|[6]Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010;6 (1) :71-79. doi:10.1016/j.stem.2009.12.001|[7]Talkhabi M, Pahlavan S, Aghdami N, Baharvand H. Ascorbic acid promotes the direct conversion of mouse fibroblasts into beating cardiomyocytes. Biochem Biophys Res Commun. 2015;463 (4) :699-705. |[8]Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012;44 (4) :398-S2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, protect from light
Scientific Category
GMP Small Molecules
Clinical Information
Phase 4

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