DMP-851

• Description :

  DMP-851 is a cyclic urea HIV protease inhibitor, with a Ki of 0.021 nM. DMP-851 shows antiviral activity against laboratory strains of HIV-l and HIV-2 as well as against primary clinical isolates derived from Zidovudine (HY-17413) -resistant samples (A018C, E, WR 10983) [1].

• CAS Number :

  [188978-02-1]

• UNSPSC :

  12352005

• Target :

  HIV; HIV Protease

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research :

  Infection

• Smiles :

  O=C1N(CC2=CC3=C(NN=C3N)C=C2)[C@H](CC4=CC=CC=C4)[C@H](O)[C@@H](O)[C@@H](CC5=CC=CC=C5)N1CCCC

• Molecular Formula :

  C31H37N5O3

• Molecular Weight :

  527.66

• References & Citations :

  [1]Rodgers JD, et al. Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol. 1998 Nov;5 (11) :R312.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  HIV-1; HIV-2