DMP 904

• Description:

  DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity[1][2].

• UNSPSC:

  12352005

• Target:

  Adenylate Cyclase; CRFR

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Neurological Disease

• Smiles:

  CC1=NC2=C(C3=CC=C(OC)C=C3C)C(C)=NN2C(NC(CC)CC)=C1

• Molecular Formula:

  C21H28N4O

• Molecular Weight:

  352.47

• References & Citations:

  [1]Li YW, et al. The pharmacology of DMP696 and DMP904, non-peptidergic CRF1 receptor antagonists. CNS Drug Rev. 2005 Spring;11 (1) :21-52.|[2]Nielsen DM, et al. Antidepressant-like activity of corticotropin-releasing factor type-1 receptor antagonists in mice. Eur J Pharmacol. 2004 Sep 19;499 (1-2) :135-46.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [202579-74-6]