DMP 696

• Description :

  DMP 696 is a selective corticotropin-releasing hormone receptor 1 (CRHR1) antagonist, used for the treatment of anxiety and depression.

• UNSPSC :

  12352005

• Target :

  CRFR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/DMP_696.html

• Purity :

  99.03

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=NN2C(N=C(C)N=C2NC(COC)COC)=C1C3=CC=C(Cl)C=C3Cl

• Molecular Formula :

  C18H21Cl2N5O2

• Molecular Weight :

  410.30

• References & Citations :

  [1]Thoeringer CK, et al. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. Neuropsychopharmacology. 2012 Feb;37 (3) :787-96.|[2]Hubbard DT, et al. Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear. Neuroscience. 2007 Dec 19;150 (4) :818-28. Epub 2007 Oct 5.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [202578-52-7]