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DMP 323

CAT: 0804-HY-117747Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-117747Size:1 Each
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Description
DMP 323 is a potent, nonpeptide cyclic urea inhibitor of HIV protease, effective against both HIV type 1 and type 2. Designed using structural information and database searching, it competitively inhibits the cleavage of both peptide and HIV-1 gag polyprotein substrates. DMP 323 shows comparable potency to other highly effective HIV protease inhibitors like A-80987 and Ro-31-8959. Importantly, its efficacy against HIV protease remains unaffected by human plasma or serum, suggesting low affinity for plasma proteins. Furthermore, DMP 323 demonstrates minimal inhibition of various mammalian proteases at concentrations much higher than those needed for HIV protease inhibition, highlighting its specificity for viral targets[1].
CAS Number
[151867-81-1]
Product Name Alternative
JCR 424; XM 323
UNSPSC
12352005
Target
HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dmp-323.html
Smiles
O=C1N(CC2=CC=C(CO)C=C2)[C@H](CC3=CC=CC=C3)[C@H](O)[C@@H](O)[C@@H](CC4=CC=CC=C4)N1CC5=CC=C(CO)C=C5
Molecular Formula
C35H38N2O5
Molecular Weight
566.69
References & Citations
[1]Potency and Selectivity of Inhibition of Human Immunodeficiency Virus Protease by a Small Nonpeptide Cyclic Urea, DMP 323
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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