DMP 777

• Description:

  DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

• Product Name Alternative:

  L-694458

• UNSPSC:

  12352005

• Target:

  Elastase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/DMP-777.html

• Purity:

  99.82

• Solubility:

  DMSO : 38.33 mg/mL (ultrasonic)

• Smiles:

  CCC[C@H] (C1=CC2=C (C=C1) OCO2) NC (N3[C@H] (C (CC) (C3=O) CC) OC4=CC=C (C=C4) C (N5CCN (CC5) C) =O) =O

• Molecular Formula:

  C31H40N4O6

• Molecular Weight:

  564.67

• References & Citations:

  [1]Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51 (3) :431-9.|[2]Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17 (6-7|[3]Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  157341-41-8