DMP 777

• Description :

  DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

• Product Name Alternative :

  L-694458

• UNSPSC :

  12352005

• Target :

  Elastase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/DMP-777.html

• Purity :

  99.82

• Solubility :

  DMSO : 38.33 mg/mL (ultrasonic)

• Smiles :

  CCC[C@H](C1=CC2=C(C=C1)OCO2)NC(N3[C@H](C(CC)(C3=O)CC)OC4=CC=C(C=C4)C(N5CCN(CC5)C)=O)=O

• Molecular Formula :

  C31H40N4O6

• Molecular Weight :

  564.67

• References & Citations :

  [1]Ogawa M, et al. Omeprazole treatment ameliorates oxyntic atrophy induced by DMP-777. Dig Dis Sci. 2006 Mar;51 (3) :431-9.|[2]Zagrobelny J, et al. Separation of the four stereoisomers of a potent inhibitor (L-694,458) of human leukocyte elastase and its determination in human plasma using achiral/chiral chromatography with column switching. J Pharm Biomed Anal. 1998 Sep 1;17 (6-7|[3]Weis VG, et al. Maturity and age influence chief cell ability to transdifferentiate into metaplasia. Am J Physiol Gastrointest Liver Physiol. 2016 Nov 23:ajpgi.00326.2016

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [157341-41-8]