Products for Research Use Only
RegisterLogin

TRK-851

CAT: 0804-HY-16979Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-16979Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
RK-851 is a highly selective and orally active δ-opioid receptor antagonist, with a negative logarithm of the antagonist concentration (pA2) of 8.84. TRK-851 exhibits the selectivity for the δ receptor of more than 100 times higher than that for the μ or κ receptors. TRK-851 exhibits a potent antitussive effect in a rat model of capsaicin-induced cough. TRK-851 can be used for research on antitussive effects[1].
CAS Number
189015-24-5
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O[C@]12[C@]34[C@](OC5=C(O)C=CC(C[C@@]2([H])N(CC4)CC6CC6)=C53)([H])C7=C(C8=CC(F)=CC9=C8N7CCC9)C1
Molecular Formula
C29H29FN2O3
Molecular Weight
472.55
References & Citations
[1]Sakami S, et al. Design and synthesis of a metabolically stable and potent antitussive agent, a novel delta opioid receptor antagonist, TRK-851. Bioorg Med Chem. 2008 Sep 1;16 (17) :7956-67.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
δ Opioid Receptor/DOR

Related Products

CatalogName
HY-164382ER-851
HY-101747AADR 851
HY-19281DMP-851
HY-W999729CRBN ligand-851
HY-101747-01ADR 851 (free base)
HY-144451TRK-IN-12
HY-146519TRK-IN-14
HY-160166TRK-IN-26
HY-146521TRK-IN-15
HY-12327Trk-IN-1

Alternative Products

CatalogName
TRC-N381200-25MGNB-851
GTR19237736-01ER-851
T23642L-01ADR-851 HCl
GTR19275497-01CRBN ligand-851
1215826Compressor 851, without water
T23642-01ADR-851 free base
PA1321-STrk-A
338192-01Trk A
T212244-01TRK-IN-32
T211064-01TRK-IN-31

Popular Products