OTX-2002

• Description:

  OTX-2002 is an mRNA encoding two bifunctional fusion proteins (ZFBD-MQ1 and ZFBD-KRAB) . OTX-2002 targets regulatory elements located within the MYC protection gene domain (IGD) and induces the methylation of DNA and histone, leading to the downregulation of MYC expression.

• UNSPSC:

  12352208

• Target:

  MRNA

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Smiles:

  [OTX-2002]

• References & Citations:

  [1]Senapedis W, Gallagher KM, Figueroa E, et al. Targeted transcriptional downregulation of MYC using epigenomic controllers demonstrates antitumor activity in hepatocellular carcinoma models. Nat Commun. 2024;15 (1) :7875.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Oligonucleotides

• Clinical Information:

  Phase 2